Japanese Encephalitis Vaccine Market Latest Innovations, Future Scope and Market Trends

Japanese encephalitis (JE) is inflammation of brain which is caused by Japanese encephalitis virus (JEV). This virus belongs to family Flaviviradae.  JEV is considered as the most important cause of encephalitis in Asia. JEV is mosquito born flavivirus, belonging to same genus as dengue. It is spread by mosquitoes of Culex sp. Pig and birds are reservoirs of the virus and help in spreading and maintaining the JEV cycle. The disease caused by the virus has no cure. Effective vaccines are available which can prevent JE. JE vaccine is recommended to be integrated into national immunization schedule where JE disease is a public concern.

Report Overview @ https://www.transparencymarketresearch.com/japanese-encephalitis-vaccine-market.html

The global Japanese encephalitis vaccine market is estimated to grow at a significant rate over the forecast period. According to WHO, the estimated annual number of clinical cases of JE are about 68000 globally. Thus rise in prevalence and incidence of the disease is one of the most important factor expected to drive the growth of global Japanese encephalitis vaccine market during the forecast period. Furthermore, rise in awareness about the disease, increase in travel and tourism, government initiative to eradicate the disease, pig farming, entry of new vaccine manufacturers, developed R & D etc, increasing mosquito nuisance are few other factors fuelling the growth of the global Japanese encephalitis market through 2025. Factors such as stringent government regulation regarding efficacy and safety, lack of awareness lack of supply of the vaccine in remote areas can be the major restraining factors for global Japanese encephalitis vaccine market during the forecast period.
The global Japanese encephalitis vaccine market can be segmented into product type, distribution channel and regions. On the basis of product type, the global Japanese encephalitis vaccine market can be divided into mouse brain derived vaccine, live attenuated vaccine, live recombinant vaccine, inactivated Vero-cell derived vaccine. Vero cell derived vaccine segment is expected to account for a significant share of the market during the forecast period since mouse brain derived vaccine  are being replaced cell based vaccine, due to higher efficacy and safety and animal ethical regulations. Based on the distribution channel the global JE vaccine market can be divided into hospital pharmacies, retail pharmacies and E-commerce.

Request Brochure @ https://www.transparencymarketresearch.com/sample/sample.php?flag=B&rep_id=37613

Geographically the global Japanese encephalitis vaccine market is divided into North America, Latin America, Europe, Asia Pacific, and Middle East and Africa. North America is anticipated to dominate the human rabies vaccine market with the largest share during the forecast period. Surge in investment from government and public sector, programs to eradicate JE and yellow fever from the region etc are few factors propelling the growth of the global market in the North America.

 Furthermore, rise in awareness, robust research activities on yellow fever and JEV, high health care expenditure etc. are some other factors leading to market growth in the region. Asia Pacific market is anticipated to register a faster growth rate during the forecast period. The Asia Pacific is the most lucrative market due to high prevalence of the JE, government induced immunization programs, growing investment in R & D sector, entry of new vaccine manufacturers in the countries like India and China, increase number of travelers in the region, medical tourism etc.  Furthermore, increase in pig farms, poultry and mosquito nuisance in the region etc, are some of the factors anticipated to drive the growth of market in the region.

Request for TOC @ https://www.transparencymarketresearch.com/sample/sample.php?flag=T&rep_id=37613

Some of the prominent players operating in the global Japanese encephalitis vaccine market are Valneva SE, Bharat Biotech, Sanofi Pasteur SA, Biological E Chengdu Institute of Biological Products Co, Ltd and others.


The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.

OTC Orthopedic Braces Market Worldwide Major Trend Outlook 2016 To 2024

Orthopedic braces are devices which are used to support and control the joints of the body. The braces can be used on the ankle, knee, hip, back, neck, elbow, fingers, and wrist. Orthopedic braces are used to control the position of limbs and initiate specific movement or motion in the body. Also, the braces can be compensated for weak muscles and to correct structural deformities.  Orthopedic braces are used extensively for diagnosis of cerebral palsy, spina bifida, spinal cord injury, scoliosis, and to deal with after stroke effects. Braces are also used after surgeries on knee joints in order to keep the joints immobile and control motion until the joints recover. Many people use braces for extra support to prevent injuries to joints. Athletes such as football and rugby players’ particularly use braces to prevent injuries. The sophisticated designs, cost effectiveness, and easy availability are driving the growth of the OTC orthopedic braces market. Custom braces and relevant designs can increase the cost of braces which may restrain the OTC orthopedic braces market growth rate during the forecast period.

Report Overview @ https://www.transparencymarketresearch.com/otc-orthopedic-braces-market.html

Orthotics is an example which is more than a shoe inserts. Orthotics manufacture and design orthoses which modifies the structure and function of the skeletal and neuromuscular system of the body. Demand for orthopedic braces has increased due to increase in the geriatric population, obesity, rising public participation in sports, orthopedic injuries among younger population, and rise in incidence of bone -degenerative diseases, all of which are driving growth in the OTC orthopedic braces market. According to the American Journal of Orthopedics, August 2016, osteoarthritis is a leading cause of disability among middle-aged and older adults, affecting nearly 27 million Americans. Increase in aging of the baby boomer population and rising obesity rates are estimated to increase osteoarthritis by 40% by 2025. Moreover, noninvasive nature of treatment using orthopedic braces and supports, reduced reimbursements offered during orthopedic surgery in developed regions such as North America and Europe are expected to propel the growth opportunities for sports players representing at a global, national or state level. High patient preference for alternative treatments, supports in prophylactic and rehabilitative use and lack of customization options for OTC orthopedic braces can hamper the growth of the global OTC orthopedic brace market during the forecast period.

Request Brochure @ https://www.transparencymarketresearch.com/sample/sample.php?flag=B&rep_id=19220

The OTC orthopedic braces market has been segmented by product type, indication, end-users, and geography. In terms of product type, the OTC orthopedic braces market is classified into foot & ankle braces, upper extremity braces, knee braces, and spinal orthoses braces. In terms of indication type, the market is classified into injury, arthritis, prophylactic, and others. According to the professor of Boston University School of Medicine, knee osteoarthritis is progressive damage to joint cartilage which leads to weakened muscles, pain and swelling. People who wore knee braces reduced pain by about 40% over 6 weeks. In terms of end users, the OTC orthopedic braces market is classified into orthopedic clinics, hospitals, pharmacies, and others. Geographically, the OTC orthopedic braces market is classified into North America, Latin America, Europe, Asia Pacific, and Middle East & Africa.

Geographically North America dominates the global OTC orthopedic braces reagents market due to increase in obesity, increase in sports activity, and rise in aging  population. Reduced reimbursement policy for surgeries and low cost of braces is expected to drive the OTC orthopedic braces reagents market in North America. Europe is the second largest market for OTC orthopedic braces reagents as there are favorable government policies regarding healthcare infrastructure and awareness programs.  Asia Pacific is expected to grow at a higher rate due to rising population, changing lifestyles, rising interest in sports activity among the population, and increasing per capita expenditure. In addition, economic growth is supporting healthcare infrastructure improvement in developing countries such as Brazil, India, and China. Thus, all these factors collectively support the growth of the OTC orthopedic braces reagents market in Asia Pacific and Latin America.

Request for TOC @ https://www.transparencymarketresearch.com/sample/sample.php?flag=T&rep_id=19220

The major players operating in the global OTC orthopedic braces reagents market include ALCARE Co., Ltd., DJO Finance LLC, DeRoyal Industries Inc., Ossur hf., Breg, Inc., 3M Company, Otto Bock HealthCare, Bauerfeind AG, BSN Medical, medi GmbH & Co. KG, and Thuasne Group.

3D Orthopedic Scanning Systems Market Opportunities by 2016 to 2024

3D orthopedic scanning systems are used to scan various body parts to diagnose and treat the defects in it. 3D orthopedic scanning system can obtain accurate 3D structure of the scanned body part to producing items that are customized to the individual. These scanners find use in orthopedic surgical practices. 3D orthopedic scanning systems help to design and develop various customizations in footwear development, design of customized orthotics, and investigations for other medical and comfort purposes related to the bones and body part. 3D orthopedic scanning systems also have various clinical and research purposes. These systems help researchers to scan a number of subjects fast and easily, store and make data available for analysis and results at a convenient time and place. 3D orthopedic scanning systems are used in surgical practices such as orthopedic, spine, ENT, cosmetic, maxillofacial, dental, neurological, and general surgical procedures. Presently, most of the 3D orthopedic scanning systems available in the global market are equipped with camera, scanner, display, and memory management systems.

Report Overview @ https://www.transparencymarketresearch.com/3d-orthopedic-scanning-systems-market.html

A number of factors affect the growth of the 3D orthopedic scanning system market. Key factors include rising demand for 3D scanning for diagnosis, development and advancement in 3D orthopedic scanner devices, and rise in global geriatric population. Other key drivers are technological advancement in scanning devices, increase in the number of cosmetic procedures, and rise in the number of orthopedic problems related to elderly population. The market is also witnessing restraints or challenges in its path such as development of other scanning technologies and stiff competition among existing 3D orthopedic scanner device manufacturers. Moreover, product recalls, government regulations for reduction of overall health care cost and subsequent upswing in bulk purchasing through INHs and GPOs (Group Purchasing Organizations) are restraining the market.
The 3D orthopedic scanning systems market can be categorized based on product type, application, and region. In terms of product type, the market can be classified into scanning system, accessories, and consumables. The scanning system segment can be further classified into sensor, camera, display, and others. The scanning system segment holds the largest share of the market. Based on application, the market can be segmented into orthopedic, spine, ENT, cosmetic, maxillofacial, dental, neurological, and others. The orthopedic segment dominates the 3D orthopedic scanning system market.

Request Brochure @ https://www.transparencymarketresearch.com/sample/sample.php?flag=B&rep_id=20684

Geographically, the 3D orthopedic scanning system market can be classified into five major regions: North America (U.S. and Canada), Europe (Germany, France, U.K., etc.), Asia Pacific (Australia, New Zealand, China, Japan, India, etc.), Latin America (Brazil, Mexico, etc.), and Middle East & Africa (GCC Countries, Saudi Arabia, South Africa, etc.). North America holds the largest share of the market due to advanced technology in this region. The emerging markets in Asia Pacific, Latin America, and Middle East & Africa are expected to register robust growth during the forecast period from 2016 to 2024. This is attributed to increasing investments by the key players operating in these countries, growing health care industry, and the aging population leading to growth in the patient population in these countries. India, China, and Brazil are expected to drive growth owing to increasing investments by government bodies to enhance health care facilities.

Request for TOC @ https://www.transparencymarketresearch.com/sample/sample.php?flag=T&rep_id=20684

Key companies operating in the global 3D orthopedic scanning system market are Elinvision, Orthopaedic Innovation Centre, TechMed 3D Inc., AGE Solutions S.r.l., FARO Technologies UK Ltd., SCANNY3D S.R.L., and 3D Systems, Inc.

Peripheral Nerve Stimulators Market Global Outlook and Overview 2017 - 2027

Peripheral nerve stimulators are electrical medical devices used to localize the nerve prior to the injection of anesthetic drug while performing regional anesthesia. It consists of two electrodes, (positive and negative electrode), disposable nerve-stimulator needles of different sizes and lengths, and catheter for continuous nerve block. The negative electrode is connected to the nerve-stimulator needle, while the positive electrode is attached to the skin electrode placed near the site of the nerve to be blocked. Peripheral nerve stimulators are used to access the degree of neuromuscular block in patients. The success of this type of regional anesthesia depends upon the precise location of the nerve. These devices generate small amounts of current, which results in muscular twitching, paresthesia, or combination of the both depending upon the nerve morphology. Electric pulse generated by these devices through a needle stimulates muscular twitching at very close proximity to nerve without touching it. This facilitates a high degree of accuracy for local anesthetic drug deposition surrounding the nerve. Characteristics of peripheral nerve stimulators include monophasic and rectangular shape, i.e. square wave stimulus, 0.2-0.3 msec duration, battery powered, digital display of delivered current, audible signal on delivery of stimulus, and multiple patterns of stimulation such as single twitch, train of four, double burst, and post tetanic count.

Report Overview @ https://www.transparencymarketresearch.com/peripheral-nerve-stimulators-market.html

Increase in popularity of regional anesthesia solely or in conjunction with general anesthesia has been boosting the demand for peripheral nerve stimulators since the last decade. The usage of peripheral nerve stimulators in regional anesthesia offers high level of comfort to anesthetists and patients as compared to the paresthesia technique. This is projected to boost the demand for these products in the near future. These devices are commonly used in orthopedic surgeries. Thus, the increase in the number of orthopedic surgical cases across the globe is expected to drive the demand for these devices. However, the high cost of these devices and availability of disposable needles and catheters for continuous blocks are the key restraining factors. Rise in number of hospitals and ambulatory surgical centers in emerging economies such as India, China, Brazil, and Mexico, and adoption of newer technologies in regional anesthesia are likely to create new opportunities for peripheral nerve stimulators during the forecast period.

Request Brochure @ https://www.transparencymarketresearch.com/sample/sample.php?flag=B&rep_id=28409

The market for peripheral nerve stimulators for regional anesthesia can be segmented based on stimulating feature, end-user, and geography. In terms of stimulating feature, the market can be sub-divided into peripheral nerve stimulator machines with Train of Four (TOF) monitoring features and peripheral nerve stimulator machines without TOF features. End-users of peripheral nerve stimulators include hospitals, ambulatory surgical centers, and others. The hospitals segment is projected to dominate the market during the forecast period owing to the rise in the number of government as well as private hospitals and academic medical institutions. The ambulatory surgical centers sub-segment is anticipated to witness exponential growth during the forecast period due to the rise in number of outpatient surgeries in these centers and favorable medical reimbursement policies for surgeries performed in these centers.

In terms of geography, the global peripheral nerve stimulator market for regional anesthesia can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America is projected to hold the major share of the global peripheral nerve stimulators market for regional anesthesia primarily due to the presence of well-established healthcare infrastructure, high per capita healthcare expenditure, and favorable medical reimbursement policies by governments and commercial players. Europe is also a key contributor to the global market for peripheral nerve stimulators for regional anesthesia. The market for peripheral nerve stimulators for regional anesthesia in Asia Pacific is projected to expand at a fast rate owing to the increase in number of hospitals, growth in healthcare infrastructure budgets by governments, and rise in number of orthopedic surgeries in the region.

Request for TOC @ https://www.transparencymarketresearch.com/sample/sample.php?flag=T&rep_id=28409


Key players operating in the global peripheral nerve stimulators market for regional anesthesia include Xavant Technology (Pty) Ltd., Vygon SA, B. Braun Melsungen AG, Teleflex Incorporated, Halyard Health, Inc., and SunMed, LLC. Of these, Teleflex, B. Braun Melsungen AG, Vygon SA, and Xavant Technologies account for major share of the global peripheral nerve stimulators market for regional anesthesia.

Medical Electronics Market Current Trends and Future Aspect Analysis 2025

Electronic devices are increasingly used for therapy, diagnosis, and rehabilitation in the field of medicine. Electromechanical equipment and medical electronics have become indispensable for providing better services to patients. Medical electronics is a branch of electronics in which medical equipment and instruments are used for medical applications such as research, diagnosis, therapy, anesthesia control, surgery, and cardiac control. Medical electronics engineering integrates medicine and environmental science with engineering practices and theories. Semiconductors have become an integral part of medical electronics equipment for reducing the cost which is changing the affordability of equipments. Medical electronic equipment are indispensable for proving better services to patients in hospitals. In medical electronics by using precise and sophisticated equipment, medical science examines, cures and treats almost all the diseases. Benefits associated with the use of medical electronic technologies include remote health data availability, precise billing mechanism, improvement in the quality of health care, increase in output accuracy, easy to update patient records, and rise in the level of patient experience.

Report Overview @ https://www.transparencymarketresearch.com/medical-electronics-market.html

Rapid advancement in IT and increasing health care consciousness has accelerated the scope for medical electronics market. Advanced technology in medical electronics include telehealth in intensive care unit (ICU), emergency department (ED) and hospital ward and skilled nursing facility (SNF). With the advent of digital stethoscopes, digital X-ray systems and handheld smart phone-sized ultrasound systems, conventional medical devices have evolved to aid medical electronics market. Rapid advancement in health care consciousness and information technology has accelerated the scope for medical electronics market. Growth in medical electronics market is influencing various demographic trends such as enhanced portability of complex monitoring and imaging systems, increase in household medical electronics equipment, and functional integration of applications and equipment in network and wireless technology.

Request Brochure @ https://www.transparencymarketresearch.com/sample/sample.php?flag=B&rep_id=34568

Rising geriatric population and increasing use of respiratory care devices are fuelling the medical electronics market. Additionally, factors such as demand for easy-to-use, personalized & advanced healthcare devices, changing lifestyle, and rising adoption of wearable electronics are expected to drive the medical electronics market. However, issues regarding cybersecurity, where health care providers and patients are subjected to security breaches and malware infections are expected to hinder the market. Rising demand for better and improved health care and developments in newer medical technologies for wireless medical devices and its technology are expected boost the medical electronics market. Moreover, factors such as increased market penetration rate of portable medical devices, increasing trend of remote patient monitoring, and high availability of electronic components such as memory devices, display technologies and microcontrollers are expected to create growth opportunities for medical electronics market. With advancement in technology, newer medical electronics devices are emerging in healthcare which is also expected to boost growth in medical electronics market.

Request for TOC @ https://www.transparencymarketresearch.com/sample/sample.php?flag=T&rep_id=34568

The global medical electronics market can be segmented based on product type, application, component, and region. In terms of product type, the market can be segmented into invasive and non-invasive. Based on application, the market is classified into diagnosis, monitoring, and treatment. In terms of component, the market is categorized into sensors, batteries, memory devices, microcontrollers, and displays. Based on geography the global medical electronics market is segmented into North America, Asia Pacific, Middle-East & Africa (MEA), South America, and Europe. North America is expected to dominate the market during the forecast period owing to the increase in demand for medical electronics and improved health care infrastructure.


Key players operating in the global medical electronics market are Texas Instruments Inc., GE Healthcare Pvt. Ltd, STMicroelectronics N.V., NXP Semiconductors N.V., Medtronic PLC., Cypress Semiconductor Corporation, Analog Devices, Inc., On Semiconductor Corporation, Siemens Healthcare Private Limited, and Philips Healthcare Pvt. Ltd.

Poisoning Treatment Market Key Manufacturers, Development Trends And Competitive Analysis 2020

The incidence of and fatalities from poisoning have increased drastically in recent years, according to figures presented by the World Health Organization. It is alarming to know that in 2004 alone, nearly 346,000 people around the world died due to deliberate or unintentional poisoning. While these numbers are increasing at a frightening pace, it is consoling to know that advancement in medicine and growing awareness about pharmacokinetics has led to the discovery and development of numerous antidotes for most poisons. Traditional methods such as gastric lavage are now being replaced by modern techniques and antidotes.

Report Overview @ https://www.transparencymarketresearch.com/poisoning-treatment-market.html

Monitoring and analyzing trends within the poisoning treatment market at national and global levels, the report provides in-depth data with regard to overall market share and size. Breaking the market down into various sub-categories, the research report discusses the factors that drive and restrict the growth of the industry.

With the help of high-quality data derived from firsthand interviews and reliable sources, and views from industry experts and analysts, the research report allows stakeholders of the poisoning treatment market to make informed business decisions.

Overview of the global poisoning treatment market 

Sedatives, pesticides, chemicals, overdose of drugs, and alcohol are some of the common agents of poisoning, cyanide being the most fatal kind. The primary factor that drives the growth of the poisoning treatment market around the world is increasing awareness among healthcare providers as well as the common populace regarding the importance of antidotes. The presence of mandatory regulations and initiatives of community education are key to saving the lives of billions.

Request Brochure @ https://www.transparencymarketresearch.com/sample/sample.php?flag=B&rep_id=3165

The regional markets for poisoning treatment are North America, Europe, Asia Pacific, and Rest of the World. Presently, North America and Europe dominate the global market owing to the availability of new and effective antidotes, presence of a flourishing pharmaceutical industry, government aid, rigorous research activities, and increased knowledge of pharmacokinetics. Countries in Asia Pacific such as India and China have been identified as regions with immense potential owing to improved healthcare infrastructure and services and growing availability of key antidotes in government as well as private hospitals. A sad yet true fact that drives the market for poisoning treatment in the low-income nations of Africa is high suicide rates, which drives the demand for various kinds of antidotes.

Request for TOC @ https://www.transparencymarketresearch.com/sample/sample.php?flag=T&rep_id=3165

Companies mentioned in the research report 

Studying the overall poisoning treatment market and its competitive environment, the research report offers information on company overview, strategic development and decisions, mergers and acquisitions, marketing and brand management, and financial standing of the major market players. Some of the notable participants of the poisoning treatment market are Cumberland Pharmaceuticals, Inc., Meridian Medical Technologies, Inc., Protherics, Inc., BTG International, Inc., Novartis AG, and Bristol-Myers Squibb

According to the research report, the global poisoning treatment market is rather consolidated, with a handful of big players dominating over more than half the market.

Penile Cancer Market – Latest Trends and Future Growth Study by 2020

Cancer, according to the International Agency for Research on Cancer (IARC) resulted in the death of around 4.6 million men worldwide in 2012. Around 14% of the world’s total annual deaths are as a result of various cancers. Modern medicine has extended the life expectancy of a cancer patient by a great margin. However newer cases are diagnosed every year globally, the present rate stands at 7.4 million newly diagnosed males annually, according to the WHO. This is commonly as a result of the changing lifestyles, unhealthy diet, hereditary factors and exposure to carcinogenic elements, cigarette smoking, etc. Male specific cancers include: prostate cancer, testicular cancer, and penile cancer. Among which prostate cancer is the most prevalent form of male cancer. Male specific cancers are generally benign/malignant tumors that rarely undergo metastasis.

Report Overview @ https://www.transparencymarketresearch.com/penile-cancer-market.html

Penile cancers are an even rarer form of cancer specific to the male reproductive organ i.e. penis, but unlike prostate and testicular cancer, they are commonly as a result of human papiloma virus (HPV), and human immunodeficiency virus (HIV) infection. According to the U.S National Cancer Institute study roughly 40% of all penile cancer is as a result of HPV infections, whereas HIV patients exhibit eight time increased risk of penile cancer. Hence penile cancer rates are high in developing countries of Africa, South Asia and South America. This is probably why vaccination for HPV virus (Gardasil or Cervarix) is regarded by a share of expert medical practitioners as a preventive measure in decreasing penile cancer rates globally. The incidence rate for penile cacner is found higher in men above 30 years of age,   Penile cancer is majorly categorized as squamous cell carcinoma, as a large majority of penile cancer patients have exhibited this form. Other even rare types include intraepithelial neoplasia, bowenoid papulosis and invasive carcinoma of the penis.

Request Brochure @ https://www.transparencymarketresearch.com/sample/sample.php?flag=B&rep_id=3573

The diagnosis of penile cancer is initially done by physical examination of the penis, this is followed by the biopsy of the outgrowth i.e. wart/ papules or skin abscess. Staging of the penile malignancy is done further to establish a timeline of disease progression. Chemotherapy, antiviral therapy and surgical excision are the common mode of treatment for penile cancer. Surgical methods are classified on the type of procedure apt to remove the tumor; circumcision, microsurgery, excision, or penectomy (castration) are the generally followed procedures. Radiation is used to prevent any reoccurrence, although the procedure can render the patient infertile.

That said, the market for male cancer therapeutics is highly fragmented hence not easily quantifiable, however the surgery and overall treatment market remains in millions of USD, with new  diagnostic screening procedures and drug combinations being patented every year, each having their own market segment. With entry of Asian players the prices too are bound to decrease, thereby potentially increasing the overall therapeutics market.

Request for TOC @ https://www.transparencymarketresearch.com/sample/sample.php?flag=T&rep_id=3573

The North American market is the highest market by volume, followed by Europe, as in these regions the number of reported cases are high in number, and so is the affordability of drugs. In developing markets of Asia and South America, their poor hygiene standards, presence of a large HIV patient population along with their overall increasing population size make for a large market, however unavailability of affordable diagnostic procedures and therapeutic drugs is thought to be the major reason why diagnosis is few in number and why the markets haven’t been proliferated as of yet. The rest of the world region is also bound to follow a similar pattern with increased awareness and diagnostic rates, the number of diagnosed individuals undergoing therapy in this region is however very small.

Some of the major companies manufacturing HPV vaccines include: GlaxoSmithKline PLC, Novartis AG, MercK & Co, etc to name a few.