Wednesday, February 27, 2019

Lexiscan Nuclear Stress Test Market by Application, Trends and Growth Rate to 2024

Global Lexiscan Nuclear Stress Test Market: Snapshot
The need for ascertaining the health of arteries to identify coronary artery disease in patients who cannot perform an adequate level of exercise has led to the demand a nuclear imaging material such as lexiscan. The stress agent is particularly used in radionuclide myocardial perfusion imaging (MPI) and is approved by the U.S. Food and Drug Administration (FDA) for injecting it intravenously in patients to crate stress conditions equivalent to exercise. The inability of performing exercise can be attributed to various factors including arthritis, poor conditioning of the heart muscles, intake of blood pressure medications, or the use of devices such as pacemakers.
MPI consists of scanning heart muscles during rest and after the patient is injected lexiscan. Traces of radioactive material is used to act as a special imager before and after lexiscan is injected into the bloodstream. Comparing images before and after helps in determining the extent of damage of coronary, any arterial blockages, or any other heart defects. If the arteries of the patient undergoing test is narrowed they will respond less to the injection of lexiscan, and hence the scans processed by computer will show decreased blood flows in the affected arteries. The need for MPI is usually recommended after a heart attack, which helps cardiologists guide decisions related to future treatment procedures such as angioplasty or coronary artery bypass surgeries. The rising prevalence of coronary artery disease in developed and developing countries is a key factor expected to boost the demand for cardiac nuclear lexiscan exercise stress test in the coming years.
Lexiscan or regadenoson is a stress agent, which typically works by increasing blood flow in the arteries of the heart. Lexiscan is specifically used for radionuclide myocardial perfusion imaging (MPI) in patients who are unable to bear adequate exercise stress. In this test, typically, patients are asked to walk on a treadmill or ride a stationary bicycle. The aim is to increase patient’s heart rate until it is adequately stressed.
The heart is a specified muscle and like other muscles in the body it needs oxygen and nutrients so that it can continuously pump blood throughout the body. Regadenoson is injected intravenously in preparation with a radiologic (X-ray) examination of blood flow through the myocardial perfusion imaging (MPI) nuclear stress test or coronary artery test.
On April 10, 2008, Lexiscan was approved by the U.S. Food and Drug Administration (FDA). It is marketed by Astellas Pharma. It is approved in the EU under the name Rapiscan. Currently, it is being marketed by GE Healthcare, which is being sold mainly in the United Kingdom (U.K.) and Germany.
MPI test is taking pictures of the blood flow in a patient’s heart. This test provides detailed anatomical images which can be used to diagnose and evaluate conditions in coronary artery disease. Coronary artery disease progresses when arteries become damaged or diseased. Usually, coronary arteries are damaged when they are accumulated with deposits called plaques. Shortness of breath is a usual indication of coronary artery disease. MPI test images can tell a doctor if a patient’s heart is bloated and can measure its overall functioning, for example ejection fraction.
The choice of lexiscan nuclear stress test modality depends on many factors. Some of the important factors are resting electrocardiogram (ECG), ability to perform exercise, and clinical signals performing the test.
The global lexiscan nuclear stress test market is driven by rise in incidence of coronary heart diseases. According to a recent analysis in the medical journal The Lancet, the number of people with peripheral arterial disease (PAD) has increased by 24% in the past ten years. Globally, millions of people are suffering with heart rhythm disorder atrial fibrillation also called AFib. Currently, nearly 2.7 million people in the U.S. have AFib. This number is expected to increase significantly due to rise in geriatric population. The formation/accumulation of plaque in the arteries in the limbs is one of the major reasons that can cause heart attack or stroke. Other causes of rise in heart diseases are smoking, obesity, and changes in lifestyle. On the other hand, side effects and safety issues related to lexiscan nuclear stress test are projected to restrain the global lexiscan nuclear stress test market. People may experience side effects depending on individual conditions. The most common side effects that followed application of lexiscan test were headache, flushing, chest pain, nausea, feeling hot, dizziness, and nausea. Other factors likely to hamper market growth are rise in cost of overall treatment and surgeries.
Key players operating in the lexiscan nuclear stress test market are Astellas Pharma, Inc. and GE Healthcare. Moreover, small number of players operate in this market at the regional level, especially in low to medium income parts of the world.

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Custom Primer Generation Service Market Size, Share & Trend | Industry Analysis Report, 2024

Primer is a small strand of DNA or RNA used in DNA synthesis as a preliminary point. The size of primers is generally not more than 30 nucleotides and these exactly match the end and beginning of the DNA section to be amplified. The primers adhere at the beginning and endpoint of DNA template, where DNA polymerase muddles and initiates the production of the new DNA strand.
The temperature, at which half of DNA molecule types form a stable double helix and remaining half are detached to solitary strand molecule, is called melting temperature of primer, generally between about 55 °C and 65 °C. Melting temperature is required to increase the length of primer and the temperature is decreased to stop or limit the length. Primers that are too small would adhere at numerous places on a lengthy DNA template, and results in non-specific copies. The primer sequence should be unique in nature to avoid the possibility of mishybridization to a similar sequence nearby. The ideal primer should not adhere to other primer and to themselves strongly, as internal loop could hamper the annealing with the template DNA. Custom primers are widely used for sequencing libraries.
The custom primer generation service market has been segmented based on type of service, application, and end-user. In terms of type of service, the market has been categorized into primer design service and primer synthesis or sequencing. The one-stop custom qPCR primer design service is designed to save money, time, and efforts by avoiding failure or complication in qPCR experiments. For a successful qPCR, a pair of good designed primers is one of the main requirements. The primer sequencing services segment comprises two types: tube sequencing and plate sequencing. Plate sequencing are of two types: short sequencing plates and ready to load plates.
In terms of application, the custom primer generation service market has been segmented into research, therapeutics, and diagnostics. The research segment has been categorized into PCR, qPCR, DNA sequencing, gene synthesis, and other research applications. The therapeutics segment has been sub-segmented into DNA/antisense oligos, RNA, nucleic acid aptamers, and immunotherapy. Increasing applications of custom primers in library preparations, nucleic acid array-based technologies, genomics, next-generation sequencing (NGS), nucleic acid-base detections, diagnostics, cell cultures, human identity testing, therapeutics, cloning, and synthetic biology and genetic engineering are likely to propel the custom prime generation service market.
In terms of end-user, the custom primer generation service market has been segmented into academic research institutes, diagnostic laboratories, pharmaceutical and biotechnology companies, and others. The diagnostics segment is expected to expand at a high CAGR owing to rising adoption of novel technologies and services in the segment. The academic research institutes segment is expected to witness strong growth during the forecast period due to rising research activities globally.
In terms of region, the custom primer generation service market has been segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America is projected to account for the major share of the global custom primer generation service market owing to increasing awareness about the applications of synthetic genes in the region. Additionally, increasing funding from public and private sector organizations for research is anticipated to boost the custom primer generation service market. Asia Pacific is the most progressive region for the custom primer generation service market due to product availability and research and development funding in the region.
Major factors boosting the growth of this market include rising demand for synthesized primer generation, increasing R&D expenses by pharmaceutical companies, and growing government participation in development of genomics.
Major players in the custom primer generation service market are Merck KGaA, Thermo Fisher Scientific Inc., Agilent Technologies, Inc., Eurofins Genomics, Bioautomation Corporation, General Electric Company, Integrated DNA Technologies, and Eurogentec S.A. Increasing competition among key players in the custom primer generation services market is likely to fuel the growth of the market during forecast period.
The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.
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Chromatography Resins Market: Analysis and Research Report by Experts 2023

Chromatography is a process to separate mixtures of colored compounds into individual components. Resins are one of the important components of chromatographic techniques. It helps in isolation of desired component from mixtures of compounds. Resins have wide array of uses in gel filtration, ion-exchange, affinity, size exclusion, hydrophobic interaction and mixed-mode chromatographic techniques. Resins are usually incorporated into chromatography devices to cover a variety of industrial/research needs such as diagnostic test development, food & drug processing and purification, and separation of biomolecules. In chromatography based purification, choice of appropriate resin is an important step since resins are crucial for ensuring effective and accurate separation of individual components.
The chromatography resins market is significantly growing under the influence of emerging biopharmaceuticals, biotechnology and food and beverages industries. Increasing demand of resins for protein purification, monoclonal antibody production, drug assessment and food processing have triggered the growth of this market. Furthermore, huge investment in research and development by life science companies, extensive academic and industry collaborations and innovation in purification technology have also driven the global chromatography resins market. The increasing application of chromatography resins in drug discovery processes has increased its demand several folds in recent years. However, the presence of other advanced analytical techniques such as electrophoresis, protein crystallization, and charged ultra filtration membranes may hamper the growth of the chromatography reagents market globally.
The global chromatography resins market has been segmented by application, technique and product type. The chromatography resins market by application is segmented into pharmaceuticals, biotechnology, food and beverages, academic research and cosmetics. Among these biotechnology, pharmaceutical and food and beverages segments account for lion share of the total chromatography resins market. Different steps of food processing, monoclonal antibody production and purification consume huge amount of chromatography resins. The chromatography resins market by techniques includes ion exchange, affinity, mixed mode, size exclusion, hydrophobic interaction, nuclear, and others. Of these, ion exchange resins constitute the largest segment market in terms of volume. However, in terms of revenue, affinity chromatography resins dominate the market primarily due to high price of affinity resins. On the basis of product type, the global chromatography resins market is categorized organic, inorganic and synthetic. Organic chromatography resins such as agarose, dextran and cellulose have gained more market acceptance as compared to inorganic and synthetic resins.
Based on geography, the affinity chromatography resins market is segmented into North America, Europe, Asia-Pacific and Rest of the World (RoW). The North American region was recognized as the largest chromatography resins market across the globe in 2013. Ongoing robust research activities for the development of drugs and biologics and the presence of major pharmaceutical, biotechnology and food and beverages companies in the region are some of the driving factors in this region. Europe was the second-largest market for chromatography resins in 2013. Asia-Pacific is expected to be an fastest growing chromatography resins market during the forecast period from 2014 to 2020. This high growth is primarily due to improving economic condition in countries such as India, China and Malaysia and increasing number of contract manufacturing and contract research organizations in Asia-Pacific region.
Some of the key players in the chromatography resins include Bio-Rad Laboratories Inc., GE Healthcare Life Sciences, Sigma- Aldrich Corporation, Thermo Fisher Scientific, Inc., Life Technology Corporation, Purolite Corporation, Pall Corporation, Tosoh Corporation, Agilent Technologies, W.R. Grace & Co., Becton Dickinson & Co, Regis Technologies , Bio-Works Company Ltd, JSR Micro Inc., and Merck KGaA.
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Sports Medicine Market Size, Share & Trend | Industry Analysis Report, 2025

Global Sports Medicine Market: Overview
Sports injuries are wounds or fractures that are caused due to exercises or sports activities. These injuries can occur due to lack of conditioning, overtraining, or improper technique or form. Absence of warm up exercise increases the risk of sports injuries. Injuries such as sprains, strain bruises, tears, and bone fracture can result from sports activities. Soft tissues such as fascia, muscles, ligaments, nerves, tendons are majorly affected by these injuries. Sports medicine is a branch of medical science dealing in physical fitness and treatment of injuries and wounds occurred due to sports or athletic physical activities. Expansion of the sports medicine market can be attributed to the rise in commercialization of sports medicine in the healthcare sector.
Developments in regenerative medicines, launch of new products and advanced treatment modalities, market penetration in emerging economies, and increasing incidences of sports injuries are few major factors driving the market. However, high cost of implant devices and surgical procedures could be one of the factor restraining the growth of the sports medicine market.
Few of the most common sports injuries that occur are ankle sprain, hamstring strain, knee injury which could be either anterior cruciate ligament (ACL) tear or Patellofemoral syndrome (caused due to repetitive movement of kneecap against thigh bone), and tennis elbow. Anterior cruciate ligament tears are the most common and severe sports injuries. Torn ACL usually requires surgery in individuals who wish to continue their sports activity.
Global Sports Medicine Market: Key Segments
Based on product type, the sports medicine market is segmented into body reconstruction products, body monitoring and evaluation, body support and recovery products, accessories. Body reconstruction products are further divided into implants, arthroscopy devices, prosthetics, orthobiologics, and fracture and ligament repair products. Body monitoring and evaluation segment is further categorized into respiratory, cardiac, musculoskeletal, and hemodynamic. Body support and recovery products are split into braces and supports, thermal therapy, physiotherapy equipment, electrostimulation, compression clothing, ultrasound therapy, and others. Accessories segment is further segregated into bandages, disinfectants, tapes, and others. Body reconstruction and repair devices held a major share of the global sports medicine market due to rise in the number of bone reconstruction, soft tissue ligament, and ligament reconstruction procedures. Body support and recovery products is anticipated to be the fastest growing segment due to the increase in demand for performance monitoring devices, braces, and support devices.
In terms of treatment area, the sports medicine market is segmented into knee injury, foot and ankle injury, hip injury, elbow & wrist injury, shoulder injury, spine injury, and other injuries. Knee injury is projected to account for the largest share of the global sports medicine market as ACL is the most common knee injury caused due to sports. According to NCBI there are approximately 100,000 - 200,000 ACL ruptures every year in the U.S. with an annual incidence of around 1 in 3500. Based on end user, the sports medicine market is divided into hospitals, orthopedic specialty clinics, and ambulatory surgical centers. The hospitals segment dominates the global sports medicine market due to availability of advanced treatment facilities.
In terms of geography, the global sports medicine market is categorized into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America is anticipated to dominate the market due to increase in sports and physical activity-related injuries and, rise in investments in sports medicine by key market players. The sports medicine market in Asia Pacific is expected to be expand at a considerable pace. Increasing government initiatives, growing research activities in sports medicine, and rising public-private collaboration for sports medicine are fueling the market. China is expected to hold a major share of the sports medicine market in Asia Pacific due to rising focus of key players on the China region for expansion of sports medicine market.
Global Sports Medicine Market: Key Players
Key players in the sports medicine market are Stryker Corporation, DJO Global, Zimmer Biomet, Wright Medical Group, Medtronic Inc., Depuy Synthes, RTI Surgical, Arthrex, Smith & Nephew, and Conmed Corporation. 
The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.
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Urology Surgery Supplies Market Competitive Strategies And Forecasts to 2025

Urology is a branch of medical science used for the treatment of urinary tract disorders in both male and female. Urology helps to diagnose, evaluate, and provide treatment for diseases of organs such as kidney, bladder, and penile. The number of urology surgeries is increasing every year across the world. Postoperative pain, blood clots, fatigue, muscle atrophy, and infections are various complications generally seen in traditional open procedures. Hence, surgeons prefer minimally invasive techniques (which include single incision procedures and robot-assisted surgeries) over conventional open surgeries. Every year new laparoscopic procedures are developed for urology surgery. The most common urology surgeries are kidney surgery, surgery of ureters, bladder surgery, and prostatic surgery. An urologist needs supplies to perform any urological surgery. Transplantation and kidney surgery are the largest segments of the urology surgery market.
Based on product type, the urology surgery supplies market has been segmented into consumable & accessories and devices. Guidewires, retrieval, and ureteral catheters are some of the devices used in urology surgery. However, the consumables & accessories segment is expected to grow at a faster rate. Most of the supplies are disposable and are for single use only. The supplies include needles, clamps, urine collection bags, and drainage bags. The guidewires and retrieval devices sub-segments are likely to grow at a steady rate. These devices are generally used in urological stenting and kidney stone management procedures. These are used as supportive devices during surgery. Uretheral catheters are used for several functions such as uretheral dilation, infusion of contrast media, and maintaining drainage during surgery. Hospitals, clinical laboratories and ambulatory surgical centers (ASCs) are the key end-users of surgical supplies. Increasing number of urinary tract infections and kidney diseases has led to the growth of the global urology surgery supplies market. In underdeveloped countries, inadequate healthcare facilities, infrastructure, and high cost of surgical instruments are the factors restraining the market.
North America dominates the urology surgery supplies market due to the growing health care infrastructure in the region and high disposable income of the population. In the U.S., bladder cancer is the fourth most common problem among men and ninth most common problem among women. Europe is the second largest urology surgery supplies market. The European Association of Urology and the European Alliance for Personalized Medicine are the two governing bodies increasing awareness about urological problems and associated effects. Increasing geriatric population and prostate cancer patients in Europe has led to the growth of the urology surgery supplies market. The market in Asia Pacific is projected to be driven by the increasing number of urinary tract infection cases and rising diabetic population. In Asia pacific region like India the local key players such as Mindray, and Urit medical etc. has led to the growth of urology surgery supplies market. The refurbished medical equipment market in Latin America is also likely to experience significant growth. Rise in disposable income and development of health care infrastructure along with increasing health care spending by people in the region boost the growth of the urology surgery supplies market.
Key players in the urology surgery supplies market are Allengers Medical Systems, Boston Scientific Corporation, Cook Medical, B. Braun Melsungen, Dornier MedTech, Hollister Incorporated, DirexGroup, Urotech, Zephyr Surgical Implants, and UroMed.
The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.
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Humanized Mouse Model Market: Segmentation, Opportunities, Trends & Future Scope to 2025

Humanized mouse models are used for basic research, safety assessment for large molecule therapeutics, modeling of certain human-specific infectious diseases, and efficacy testing of immunotherapy approaches. The human protein is expressed while the mouse protein is suppressed in all cells and tissues. Humanized mouse models are important tools required to conduct preclinical research, mimic human pathological conditions, test compound efficacy, and measure its effects on human proteins. The model requires accurate risk assessment and thorough analysis to preserve the physiological expression and regulation of the human gene inserted into the mouse genome. In order to determine the optimal expression and functionality of the human protein in a mouse environment, the genes and proteins of both, the mouse and human, are analyzed for accuracy and structure. Humanized mouse models are used in biomedical research including cancer biology, regenerative medicine, human hematopoiesis, infectious diseases, transplantation, and autoimmunity. They enable better understanding of disease pathways and ultimately improve the translational value of preclinical studies.
Technological advancements, growing prevalence of cancer, research & development activities, and the rising adoption of personalized medicines are factors predicted to drive the global humanized mouse model market. According to the World Health Organization, cancer is the second leading cause of death globally and was responsible for 8.8 million deaths in 2015. Globally, nearly 1 in 6 deaths is caused by cancer. Government investment too plays a key role in motivating the market. On the other hand, regulations & laws formulated for ethical use of animals and increased use of rat models may hinder the global humanized mouse model market.
The market has been segmented by model type into the genetic and cell-based varieties. The latter is further segmented into the PBMC, BLT, and CD34 categories. The growing application of CD34 models is expected to trigger the demand for them in the near future. In terms of application, the humanized mouse model market is classified into the following groups: oncology, immunology, infectious diseases, neuroscience, hematopoiesis, toxicology, and others. Based on end-user, the humanized mouse model market is categorized into the following sections: contract research organizations (CROs), pharmaceutical & biotechnology companies, and academic & research institutions.
Geographically, the humanized mouse model market is distributed over North America, Latin America, Europe, Asia Pacific, and Middle East & Africa. North America dominated the market due to preclinical activities by CROs, pharmaceutical R&D activities in the U.S., availability of support for research, growing monoclonal antibody production, increasing stem cell research in Canada, and government support for development of protein drugs. Europe is the second leading market for humanized mouse models owing to the increasing number of research and development activities. Asia Pacific is likely to grow at a higher rate on account of the burgeoning biomedical and medical research industries, increasing investments from the government & private sector, rising pharmaceutical & biotech R&D activities, and growing presence of global players in India. The availability of target patient pool as well as low-cost clinical trials are also important factors which are projected to propel the humanized mouse model market in Asia Pacific.
Key players operating in this market include The Jackson Laboratory, Taconic Biosciences, Inc., Vitalstar Biotechnology Co., HuMurine Technologies, Ltd., Crown Bioscience Inc., Ingenious Targeting Laboratory, Axenis S.A.S, Trans Genic Inc., Harbour Antibodies BV, and GenOway S.A.
The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.
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Cold Plasma Market Key Manufacturers, Development Trends And Competitive Analysis 2024

Cold Plasma Market: Overview
Cold plasma, popularly known as non-thermal plasma, is the new cutting edge concept that has wide applications in medical devices. The technology has transformed various medical specialties such as cardiology, dermatology, gastroenterology, and oncology and has been extensively used to assist surgeries related to these areas. Cold plasma has wide ranging applications in bioengineering and to provide antimicrobial treatment food processing propelling the growth of cold plasma market. Recently, the emerging application of cold plasma in cancer therapies is an exciting field and is expected to significantly affect the current researches in cancer therapeutics, driving the evolution of the cold plasma market.
The report offers in-depth insights into key market drivers and restraints, current trends, recent developments, regulatory framework, and emerging opportunities that can be capitalized by the market players. The study is prepared with the help of extensive secondary and primary researches and provides analysis of the market share and size of key applications segments.
Recent technological advances and disruptive technologies expected to alter the competitive dynamics are analyzed in the report. The strategically motivated insights included in the report are intended to help the key market players in identifying lucrative avenues and evidence-based decision making.
Cold Plasma Market: Trends and Opportunities
The cold plasma market is primarily driven by unique benefits of cold plasma techniques, demand for innovative production techniques in textile industry and other end-use industries, and soaring concerns of safety and decontamination for processed foods. Cold plasma has been increasingly used to make self-decontaminating filters and in decontamination of various food, particularly meat and poultry packaging. This has propelled the growth of the market.
Considerable capital investment involved in developing cost plasma technologies and their limited commercialization are likely to impede the growth of the market to some extent. However, the expanding applications of cold plasma in various end-use industries such as such as food, agriculture, and polymers and plastics segments across developing nations are the factors boosting the market.
The enhanced efficacy of cold plasma in devising therapies for various types of cancer, such as lung, breast, bladder, and skin is expected to create vast opportunities for the market players along the forecast period. A large number of in-vitro and in-vivo studies have confirmed that cold plasma technology can be used to selectively kill cancer cells. Key characteristics that have boosted the use of cold plasma in cancer therapies are plasma-induced apoptosis and in decreasing the cell migration velocity. This helps in localizing the affected tissue area and by reducing the risk of cancer metastasis.
Cold Plasma Market: Regional Outlook
Europe and North America are prominent markets for cold plasma technology. The impressive growth is driven by the wide presence of global cold plasma companies that have facilitated the accessibility of the technologies. However, Latin America and Asia-Pacific are expected to showcase promising opportunities for companies in the cold plasma market. The regional growth is driven by rising economical and infrastructural activities across various emerging countries, such as China, Thailand, India, and Indonesia. Furthermore, significant technological developments in the electronics and semiconductor industry are expected to fuel the growth of the regional market.
Cold Plasma Market: Competitive Landscape
Leading players are adopting mergers and acquisitions as the key strategy to consolidate their presence in different emerging markets. Prominent companies operating in this market include Nordson Corporation, Bovie Medical Corporation, Plasmatreat GmbH, Adtec Plasma Technology Co., Ltd., Enercon Industries Corporation, Neoplas Tools GmbH, Europlasma NV, and Tantec A/S Henniker Plasma.
The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications.
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